Endotracheal compared with intravenous injection of 3 mg/kg of lignocaine

Summary The arterial and venous concentrations differ quantitatively and temporally after the administration of lignocaine via any route. Hence, arterial and venous levels were studied simultaneously following intravenous and tracheal injection in dogs, at 5, 15, 30, 60 seconds and at 5, 15, 30, 60, 120 minutes. Following intravenous injection, concentrations in the carotid artery were consistently higher for 60 seconds, the jugular vein levels were higher at 5 minutes and they were parallel thereafter. Following tracheal administration the highest arterial concentration was reached in 15 minutes and the highest venous levels at 5 minutes.