1975•Journal of Biological ChemistryOpen access

The generation of O2-by the interaction of the hemolytic agent, phenylhydrazine, with human hemoglobin.

Burton D. Goldberg, Alexa Stern

Abstract

Phenylhydrazine reacts with adult oxy- or methemoglobin in the presence of molecular oxygen to generate O2-. The mechanism of the reaction apparently differs in each case. The generation of O2- is monitored by following the reduction of ferricytochrome c or the oxidation of epinephrine.

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Key concepts: Phenylhydrazine, Hemoglobin, Chemistry, Methemoglobin, Autoxidation, Hemolysis, Hydrogen peroxide, Biochemistry