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Metabolic Engineering: Principles and Methodologies

Gregory Stephanopoulos, Aristos Aristidou, Jens Nielsen

Abstract

The Essence of Metabolic Engineering. Review of Cellular Metabolism. Comprehensive Models for Cellular Reactions. Material Balances and Data Consistency. Regulation of Metabolic Pathways. Examples of Pathway Manipulations: Metabolic Engineering in Practice. Metabolic Pathway Synthesis. Metabolic Flux Analysis. Methods for the Experimental Determination of Metabolic Fluxes by Isotope Labeling. Applications of Metabolic Flux Analysis. Metabolic Control Analysis. Analysis of Structure of Metabolic Networks. Flux Analysis of Metabolic Networks. Thermodynamics of Cellular Processes. Glossary. Subject Index.

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Key concepts: Metabolic flux analysis, Metabolic engineering, Metabolic pathway, Metabolic network, Flux (metallurgy), Metabolic control analysis, Consistency (knowledge bases), Glossary