2003•Current Protocols in Cell BiologyRequires access

The Chick Chorioallantoic Membrane as an In Vivo Angiogenesis Model

Maria Lourdes Ponce, Hynda K. Kleinmann

Abstract

The chick chorioallantoic membrane (CAM) assay for angiogenic activity is a model originally developed to study the angiogenic activity of tumor samples. It is an in vivo assay that can be readily performed in any laboratory setting. The effects of a test compound on angiogenesis are tested by exposing day 10 embryos to the compound and following the patterns of blood vessel development, scoring the appearance of the CAM at day 12 or 13.

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Key concepts: Chorioallantoic membrane, Angiogenesis, In vivo, Embryo, Cell biology, In vitro, Biology, Blood vessel