2001•Methods and principles in medicinal chemistryRequires access
Protein Structure Prediction
Ralf Zimmer, Thomas Lengauer
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Abstract
This chapter contains sections titled: Overview Definition of terms What is covered in this chapter Data Input data Output data Additional input data Structure comparison and classification Scoring functions and (empirical) energy potentials Methods Secondary structure prediction Knowledge-based 3D structure prediction Results Remote homology detection Structural genomics Selecting targets for structural genomics Genome annotation Sequence-to-structure-to-function paradigm Validation of predictions Benchmark set tests Blind prediction experiments (CASP) Conclusion: strengths and limitations Threading Strengths Limitations Accessibility