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2009•Journal of Tropical MedicineOpen access

Pathogenesis of D-galactosamine (D-GalN)- and lipopolysaccharides (LPS)-induced fulminant hepatic failure.

Hai‐Peng Zhu, Zhiliang Gao, Chan Xie, Yubao Zheng, Liang Peng

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Abstract

Objective To study the pathogenesis of D-galactosamine(D-GalN)-and lipopolysaccharides(LPS)-induced fulminant hepatic failure.Methods Fulminant hepatic failure was induced in male Sprague-Dawley rats by intraperitoneal injection with D-GalN(1 250 mg / kg) and LPS(200 μg / kg).Biochemical indexes in rat serum were measured and the pathological change of hepatic tissue was examined.Results D-GalN and LPS caused a lethal hepatic injury in rat.The levels of TNF-α and IL-1β in serum were increased.The levels of GSH, GR and SOD in the liver were decreased, while the levels of MDA, NO, T-NOS and iNOS were increased after the treatment.Conclusion D-GalN and LPS can cause fulminant hepatic failure.The increase in the production of inflammatory cytokines and free radicals may contribute to the pathological damage of the liver.

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Objective To study the pathogenesis of D-galactosamine(D-GalN)-and lipopolysaccharides(LPS)-induced fulminant hepatic failure.Methods Fulminant hepatic failure was induced in male Sprague-Dawley rats by intraperitoneal injection with D-GalN(1 250 mg / kg) and LPS(200 μg / kg).Biochemical indexes in rat serum were measured and the pathological change of hepatic tissue was examined.Results D-GalN and LPS caused a lethal hepatic injury in rat.The levels of TNF-α and IL-1β in serum were increased.The levels of GSH, GR and SOD in the liver were decreased, while the levels of MDA, NO, T-NOS and iNOS were increased after the treatment.Conclusion D-GalN and LPS can cause fulminant hepatic failure.The increase in the production of inflammatory cytokines and free radicals may contribute to the pathological damage of the liver.

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Available abstract

Objective To study the pathogenesis of D-galactosamine(D-GalN)-and lipopolysaccharides(LPS)-induced fulminant hepatic failure.Methods Fulminant hepatic failure was induced in male Sprague-Dawley rats by intraperitoneal injection with D-GalN(1 250 mg / kg) and LPS(200 μg / kg).Biochemical indexes in rat serum were measured and the pathological change of hepatic tissue was examined.Results D-GalN and LPS caused a lethal hepatic injury in rat.The levels of TNF-α and IL-1β in serum were increased.The levels of GSH, GR and SOD in the liver were decreased, while the levels of MDA, NO, T-NOS and iNOS were increased after the treatment.Conclusion D-GalN and LPS can cause fulminant hepatic failure.The increase in the production of inflammatory cytokines and free radicals may contribute to the pathological damage of the liver.

Key concepts: Fulminant hepatic failure, Pathogenesis, Galactosamine, Fulminant, Internal medicine, Intraperitoneal injection, Medicine, Pathological

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Pathogenesis of D-galactosamine (D-GalN)- and lipopolysaccharides (LPS)-induced fulminant hepatic failure. — Research Paper | ScholarLens