2014•Methods and principles in medicinal chemistryRequires access
Mood and Anxiety Disorders
Guy Griebel, Sandra Beeské
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Abstract
The search for novel drugs for treating mood and anxiety disorders is driven by the growing medical need to improve on the effectiveness and side-effect profile of currently available therapies. Preclinical research have devised numerous ways to test for anxiety and mood disorders, with well over 100 tests and models. The amount of data generated by anxiolytic and antidepressant drug discovery studies is vast and has led to numerous new molecules being progressed into the clinic. However, clinical studies have been unable to confirm the promise predicted by studies in animal models. Here we identify a number of key issues in the modelling of anxiety and mood disorders and suggest recommendations for how drug discovery in these fields might be made more effective in the future.