Glucose Transport in the Renal Proximal Tubule

The sections in this article are: General Characteristics Glucose Handling by the Whole Kidney Tubular Site of Reabsorption D-Glucose Handling by the Intact Proximal Tubule Current Understanding of the Mechanism of Glucose Reabsorption Components of the Reabsorptive Mechanism Energetics: Gradient Hypothesis Na+ Dependence of Luminal versus Basolateral D-glucose Transport Kinetics and Stoichiometry Systematics of D-Glucose Reabsorption at the Cellular and Tubular Levels Specificity Characteristics Abnormalities of Glucose Reabsorption in the Renal Tubule Renal Glycosuria Fanconi's Syndrome Specific Defects of D-Glucose Transport Molecular Characterization of the Components of the D-Glucose Reabsorptive Pathway Across the Renal Proximal Tubule The Luminal Na+-Dependent D-Glucose Carrier The Basolateral Na+-Independent D-Glucose Carrier Molecular Mechanism of Operation of the Na+-Dependent D-Glucose Transporter Conclusion