2013•Unpublished venueRequires access

Development of Therapeutic Strategies for the Transthyretin Amyloidoses

Colleen Fearns, Stephen Connelly, Evan T. Powers, Jeffery W. Kelly

Abstract

This chapter contains sections titled: Introduction to Transthyretin Structure and Function Introduction to Amyloid Diseases in General Mechanism of Transthyretin Amyloidogenesis Kinetic Stabilization of the Transthyretin Tetramer through Small-Molecule Binding Assessment of Diflunisal for Treatment of Transthyretin Amyloidosis Tafamidis, the First Approved Drug for Treatment of a Transthyretin Amyloidosis Summary References

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Available abstract

Key concepts: Transthyretin, Diflunisal, Tetramer, Amyloidosis, Amyloid (mycology), Amyloid fibril, Chemistry, Medicine