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2015•European Journal of DermatologyRequires access

Osteomalacia induced by a phosphaturic mesenchymal tumor secreting fibroblast growth factor 23

Konosuke Nagae, Hiroshi Uchi, Takamichi Ito, Yoichi Moroi, Yoshinao Oda, Masutaka Furue

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Abstract

Tumor-induced osteomalacia (TIO) is a rare paraneoplastic condition characterised by the presence of a tumor, hypophosphatemia caused by renal phosphate wasting and low serum concentration of 1,25-dihydroxyvitamin D [1,25(OH)2D], with clinical and histological evidence of osteomalacia [1-4]. Hypophosphatemia subsequently causes muscle weakness, bone pain and multiple fractures [1]. Most cases of TIO are associated with mesenchymal tumors secreting fibroblast growth factor 23 (FGF23) [1], which was [...]

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Tumor-induced osteomalacia (TIO) is a rare paraneoplastic condition characterised by the presence of a tumor, hypophosphatemia caused by renal phosphate wasting and low serum concentration of 1,25-dihydroxyvitamin D [1,25(OH)2D], with clinical and histological evidence of osteomalacia [1-4]. Hypophosphatemia subsequently causes muscle weakness, bone pain and multiple fractures [1]. Most cases of TIO are associated with mesenchymal tumors secreting fibroblast growth factor 23 (FGF23) [1], which was [...]

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Available abstract

Tumor-induced osteomalacia (TIO) is a rare paraneoplastic condition characterised by the presence of a tumor, hypophosphatemia caused by renal phosphate wasting and low serum concentration of 1,25-dihydroxyvitamin D [1,25(OH)2D], with clinical and histological evidence of osteomalacia [1-4]. Hypophosphatemia subsequently causes muscle weakness, bone pain and multiple fractures [1]. Most cases of TIO are associated with mesenchymal tumors secreting fibroblast growth factor 23 (FGF23) [1], which was [...]

Key concepts: Hypophosphatemia, Osteomalacia, Fibroblast growth factor 23, Medicine, Mesenchymal stem cell, Wasting, Fibroblast growth factor, Muscle weakness

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