Biotransformation: A Balance between Bioactivation and Detoxification

This chapter identified the fundamental principles of foreign compound (xenobiotic) modification by the body and discusses: how xenobiotics enter, circulate, and leave the body; the sites of metabolism of the xenobiotic within the body; the chemistry and enzymology of xenobiotic metabolism; the bioactivation as well as inactivation of xenobiotics during metabolism; and the variations in xenobiotic metabolism resulting from prior or concomitant exposure to xenobiotics and from physiological factors.