2014•Unpublished venueRequires access

Neuraminidase Inhibitors for the Treatment of Influenza: Design and Discovery of Zanamivir and Oseltamivir

Arun K. Ghosh, Sandra Gemma

Abstract

This chapter describes the design and development of neuraminidase inhibitors, zanamivir and oseltamivir, for the treatment of influenza virus infections. The chapter provides X-ray structural studies of sialic acid and neuraminidase complex, design of zanamivir, design of carbocyclic neuraminidase inhibitors, evolution of oseltamivir, and X-ray structural studies of neuraminidase–inhibitor complexes.

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Available abstract

Key concepts: Zanamivir, Neuraminidase, Oseltamivir, Neuraminidase inhibitor, Virology, Sialidase, Sialic acid, Virus