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2004•Unpublished venueRequires access

Drug Efflux and Protein Export through Channel‐Tunnels

Christian Andersen

Open publisher page 2 citations

Abstract

This chapter contains sections titled: Introduction Channel-tunnel-dependent Export Systems The Type I Secretion System Substrates The Inner Membrane Transporters of Type I Secretion Systems The Accessory Protein of the Type I Secretion System Efflux Pumps The Inner Membrane Transporters of Channel-tunnel-dependent Efflux Pumps Accessory Proteins of Multidrug Efflux Pumps Comparison of Channel-tunnel-dependent Export Systems in E. coli and P. aeruginosa Channel-Tunnels The Structure of TolC The Channel Domain The Tunnel Domain Electrophysiological Characterization of TolC The Role of Aspartate Residues at the Periplasmic Entrance Opening of the Periplasmic Entrance Model for TolC-dependent Export The Role of the Accessory Protein The Mechanism of Protein Secretion The Mechanism of Efflux Pumps Substrate Binding of Different Transporters Export of Substances by RND Transporters Exclusively from the Periplasm? Conclusion

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What this paper is about

This chapter contains sections titled: Introduction Channel-tunnel-dependent Export Systems The Type I Secretion System Substrates The Inner Membrane Transporters of Type I Secretion Systems The Accessory Protein of the Type I Secretion System Efflux Pumps The Inner Membrane Transporters of Channel-tunnel-dependent Efflux Pumps Accessory Proteins of Multidrug Efflux Pumps Comparison of Channel-tunnel-dependent Export Systems in E. coli and P. aeruginosa Channel-Tunnels The Structure of TolC The Channel Domain The Tunnel Domain Electrophysiological Characterization of TolC The Role of Aspartate Residues at the Periplasmic Entrance Opening of the Periplasmic Entrance Model for TolC-dependent Export The Role of the Accessory Protein The Mechanism of Protein Secretion The Mechanism of Efflux Pumps Substrate Binding of Different Transporters Export of Substances by RND Transporters Exclusively from the Periplasm? Conclusion

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Available abstract

This chapter contains sections titled: Introduction Channel-tunnel-dependent Export Systems The Type I Secretion System Substrates The Inner Membrane Transporters of Type I Secretion Systems The Accessory Protein of the Type I Secretion System Efflux Pumps The Inner Membrane Transporters of Channel-tunnel-dependent Efflux Pumps Accessory Proteins of Multidrug Efflux Pumps Comparison of Channel-tunnel-dependent Export Systems in E. coli and P. aeruginosa Channel-Tunnels The Structure of TolC The Channel Domain The Tunnel Domain Electrophysiological Characterization of TolC The Role of Aspartate Residues at the Periplasmic Entrance Opening of the Periplasmic Entrance Model for TolC-dependent Export The Role of the Accessory Protein The Mechanism of Protein Secretion The Mechanism of Efflux Pumps Substrate Binding of Different Transporters Export of Substances by RND Transporters Exclusively from the Periplasm? Conclusion

Key concepts: Periplasmic space, Efflux, Secretion, Inner membrane, Transporter, Transport protein, Membrane transport protein, Cell biology

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