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1992•Journal of VirologyOpen access

Effects of altering palmitylation sites on biosynthesis and function of the influenza virus hemagglutinin

Hassan Y. Naim, Bilal Amarneh, Nicholas T. Ktistakis, Michael G. Roth

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Abstract

Mutagenesis studies indicated that the three cytoplasmic cysteines of the influenza virus A/Japan/305/57 hemagglutinin (HA) are all palmitylated, but to an unequal extent. Replacement of all three cysteines abolished palmitylation, but affected neither HA biosynthesis nor function. Palmitate was not required for HA to be incorporated into virions.

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What this paper is about

Mutagenesis studies indicated that the three cytoplasmic cysteines of the influenza virus A/Japan/305/57 hemagglutinin (HA) are all palmitylated, but to an unequal extent. Replacement of all three cysteines abolished palmitylation, but affected neither HA biosynthesis nor function. Palmitate was not required for HA to be incorporated into virions.

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Available abstract

Mutagenesis studies indicated that the three cytoplasmic cysteines of the influenza virus A/Japan/305/57 hemagglutinin (HA) are all palmitylated, but to an unequal extent. Replacement of all three cysteines abolished palmitylation, but affected neither HA biosynthesis nor function. Palmitate was not required for HA to be incorporated into virions.

Key concepts: Biology, Hemagglutinin (influenza), Virus, Biosynthesis, Influenza A virus, Orthomyxoviridae, Virology, Mutagenesis

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Effects of altering palmitylation sites on biosynthesis and function of the influenza virus hemagglutinin — Research Paper | ScholarLens