Hematological Malignancies Uncommon Presentations of Plasma Cell Dyscrasias

Plasma cell dyscrasias are a group of lymphoproliferative disorders characterized by proliferation of plasma cells and often by the production of a monoclonal protein. More common plasma cell dyscrasias (multiple myeloma, amyloidosis and monoclonal gammopathy of undetermined significance) are beyond the scope of this chapter. Other unusual lymphoproliferative disorders will be reviewed in Chapter 47. For the puposes of this chapter, uncommon plasma cell dyscrasias are defined as plasma cell leukemia, nonsecretory multiple myeloma, immunoglobulin D myeloma, immunoglobulin E myeloma, immunoglobulin M myeloma, Waldenström macroglobulinemia, heavy chain disease, POEMS syndrome (osteosclerotic myeloma), and solitary plasmacytomas.