1990•FEBS LettersOpen access

The biological activity of retinoids in melanoma cells

Christopher P.F. Redfern, Ann K. Daly, Julie A.E. Latham, Carole Todd

Abstract

The expression of mRNA for retinoic acid receptor beta (RAR-beta) was induced by all trans-retinoic acid in murine S91 melanoma cells. The induction of RAR-beta was dose-dependent, rapid and insensitive to cycloheximide. Both 13-cis-retinoic acid and 3,4-didehydro-all trans-retinoic acid also induced expression of RAR-beta but were only effective at concentrations 100-fold greater than all trans-retinoic acid. The expression of RAR-alpha and RAR-gamma was unaffected by retinoic acid.

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Key concepts: Melanoma, Chemistry, Biological activity, Cancer research, Dermatology, Medicine, Biochemistry, In vitro