Endothelin Receptor Subtypes and Tissue Distribution

Subsequent to the realization that endothelial cells are important regulators of vascular, immunological, and probably many other functions, endothelial cell biology has rapidly expanded into a distinct discipline. Numerous endothelial-derived factors have been identified as important contributors in the regulation of vascular tone, including relaxing or contracting substances, such as prostacyclin, nitric oxide, and endothelin.