Uptake of radioactive phosphorus in experimental tumors. II. effect of vascularity on radioactive uptake in neoplastic, inflammatory, and normal ocular tissue.

Summary The effect of vascularity on the uptake of radio-active phosphorus was investigated in the following manner: 1.Inflammatory lesions of the eye were induced, and the accumulation of P 32 by such lesions was compared with that measured in normal ocular tissue. After an initial rise during the first 10 minutes, the accumulation of P 32 was essentially equal in both groups. 2.Perfusion studies in rabbit eyes containing the Brown-Pearce carcinoma in the anterior chambers confirmed the results of previous investigations showing differential uptake of radioactive phosphorus by normal and neoplastic ocular tissues. Variations in accumulation of P 32 by the individual neoplasms was explained on the basis of “tissue geometry.”. 3.Comparative measurements of the uptake of P 32 and iodinated (I 131 ) serum albumin were made in tumor tissue, normal tissue, and blood. Curves obtained may be interpreted as representing the effect of vascularity and also tissue accumulation of radioactivity.