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Vibrio cholerae and cholera : molecular to global perspectives

Kaye Wachsmuth, Paul A. Blake, Ørjan Olsvik

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Abstract

Introduction The bacterium Vibrio cholerae, Isolation and identification of toxigenic Vibrio cholerae 01 from fecal specimens Toxigenic Vibrio cholerae in food and water Detection of cholera toxin genes Detection of toxins of Vibrio cholerae 01 and non-01 Non-toxigenic Vibrio cholerae 01 infections in the United States Molecular basis for O-antigen biosynthesis in Vibrio cholerae 01 Ogawa-Inaba switching Non-O group 1 Vibrio cholerae Vibrios in the environment Serologic diagnosis of Vibrio cholerae 01 infection Virulence factors Toxins of Vibrio cholerae 01 Regulation of toxin (CT) expressions The toxin-coregulated pilus: biogenesis and function Animal models in cholera research Cholera: the disease Cholera: pathophysiology Immunity to Vibrio cholerae infection Host susceptibility Epidemiology and surveillance Cholera before 1970 The African epidemic 1970-92 Endemic cholera in Australia and the United States The Latin American epidemic Transmission of cholera Molecular epidemiology of Vibrio cholerae 01 Cholera surveillance Vaccines Polysaccharide-protein conjugate vaccines for prevention of cholera Molecular recombinant cholera vaccines Protective oral cholera vaccine based on a combination of cholera toxin B subunit and inactivated Cholera vibrios Public health consideration for the use of cholera vaccines in cholera control programs Cholera: the future Cholera: unanswered questions

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What this paper is about

Introduction The bacterium Vibrio cholerae, Isolation and identification of toxigenic Vibrio cholerae 01 from fecal specimens Toxigenic Vibrio cholerae in food and water Detection of cholera toxin genes Detection of toxins of Vibrio cholerae 01 and non-01 Non-toxigenic Vibrio cholerae 01 infections in the United States Molecular basis for O-antigen biosynthesis in Vibrio cholerae 01 Ogawa-Inaba switching Non-O group 1 Vibrio cholerae Vibrios in the environment Serologic diagnosis of Vibrio cholerae 01 infection Virulence factors Toxins of Vibrio cholerae 01 Regulation of toxin (CT) expressions The toxin-coregulated pilus: biogenesis and function Animal models in cholera research Cholera: the disease Cholera: pathophysiology Immunity to Vibrio cholerae infection Host susceptibility Epidemiology and surveillance Cholera before 1970 The African epidemic 1970-92 Endemic cholera in Australia and the United States The Latin American epidemic Transmission of cholera Molecular epidemiology of Vibrio cholerae 01 Cholera surveillance Vaccines Polysaccharide-protein conjugate vaccines for prevention of cholera Molecular recombinant cholera vaccines Protective oral cholera vaccine based on a combination of cholera toxin B subunit and inactivated Cholera vibrios Public health consideration for the use of cholera vaccines in cholera control programs Cholera: the future Cholera: unanswered questions

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Available abstract

Introduction The bacterium Vibrio cholerae, Isolation and identification of toxigenic Vibrio cholerae 01 from fecal specimens Toxigenic Vibrio cholerae in food and water Detection of cholera toxin genes Detection of toxins of Vibrio cholerae 01 and non-01 Non-toxigenic Vibrio cholerae 01 infections in the United States Molecular basis for O-antigen biosynthesis in Vibrio cholerae 01 Ogawa-Inaba switching Non-O group 1 Vibrio cholerae Vibrios in the environment Serologic diagnosis of Vibrio cholerae 01 infection Virulence factors Toxins of Vibrio cholerae 01 Regulation of toxin (CT) expressions The toxin-coregulated pilus: biogenesis and function Animal models in cholera research Cholera: the disease Cholera: pathophysiology Immunity to Vibrio cholerae infection Host susceptibility Epidemiology and surveillance Cholera before 1970 The African epidemic 1970-92 Endemic cholera in Australia and the United States The Latin American epidemic Transmission of cholera Molecular epidemiology of Vibrio cholerae 01 Cholera surveillance Vaccines Polysaccharide-protein conjugate vaccines for prevention of cholera Molecular recombinant cholera vaccines Protective oral cholera vaccine based on a combination of cholera toxin B subunit and inactivated Cholera vibrios Public health consideration for the use of cholera vaccines in cholera control programs Cholera: the future Cholera: unanswered questions

Key concepts: Vibrio cholerae, Cholera, Cholera toxin, Microbiology, Cholera vaccine, El Tor, Biology, Vibrionaceae

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