2013•Archiv der PharmazieRequires access

Resveratrol Derived Butyrylcholinesterase Inhibitors

René Csük, Sabrina Albert, Ralph Kluge, Dieter Ströhl

Abstract

Novel polyhydroxylated (E)-stilbenes were synthesized by Mizoroki-Heck reactions and tested for their ability to inhibit the enzymes acetyl- and butyrylcholinesterase. Several of them are good inhibitors of butyrylcholinesterase; one of them carrying an extra fluorine substituent is a 94-fold stronger inhibitor of butyrylcholinesterase than of acetylcholinesterase.

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Available abstract

Key concepts: Butyrylcholinesterase, Chemistry, Acetylcholinesterase, Cholinesterase, Substituent, Resveratrol, Enzyme, Biochemistry