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Pharmacokinetic Interactions of Antihypertensive Drugs with Citrus Juices

Yoshihiro Uesawa

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Abstract

Felodipine 5 mg tablet was administered with 350 mL double-strength GFJ (black squares) or water (white squares).This figure was cited from the literature (Bailey, 1998) Fig. 1.Plasma felodipine concentration-time profile. Antihypertensive drugs related with the GFJ-interactionsConcomitant administration of GFJ with a variety of drugs including antihypertensive drugs results in enhancement of plasma concentrations of the drugs.The first example of a GFJ interaction was an increase in levels of the dihydropyridine calcium channel antagonists, felodipine and nifedipine (Bailey et al., 1991), but at least 13 drugs in this category also interact with GFJ: amlodipine (

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What this paper is about

Felodipine 5 mg tablet was administered with 350 mL double-strength GFJ (black squares) or water (white squares).This figure was cited from the literature (Bailey, 1998) Fig. 1.Plasma felodipine concentration-time profile. Antihypertensive drugs related with the GFJ-interactionsConcomitant administration of GFJ with a variety of drugs including antihypertensive drugs results in enhancement of plasma concentrations of the drugs.The first example of a GFJ interaction was an increase in levels of the dihydropyridine calcium channel antagonists, felodipine and nifedipine (Bailey et al., 1991), but at least 13 drugs in this category also interact with GFJ: amlodipine (

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Available abstract

Felodipine 5 mg tablet was administered with 350 mL double-strength GFJ (black squares) or water (white squares).This figure was cited from the literature (Bailey, 1998) Fig. 1.Plasma felodipine concentration-time profile. Antihypertensive drugs related with the GFJ-interactionsConcomitant administration of GFJ with a variety of drugs including antihypertensive drugs results in enhancement of plasma concentrations of the drugs.The first example of a GFJ interaction was an increase in levels of the dihydropyridine calcium channel antagonists, felodipine and nifedipine (Bailey et al., 1991), but at least 13 drugs in this category also interact with GFJ: amlodipine (

Key concepts: Pharmacokinetics, Pharmacology, Traditional medicine, Chemistry, Medicine

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