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2011•Chinese Journal of Natural MedicinesRequires access

Coptidis Rhizoma Water Extract Stimulates 5′-AMP-Activated Protein Kinase in Rat Skeletal Muscle

Xiao Ma, Tatsuro Egawa, Rieko Oshima, Eriko Kurogi, Hiroko Tanabe, Satoshi Tsuda, Tatsuya Hayashi

Open publisher page 4 citations

Abstract

Aim Coptidis Rhizoma (CR), the dried rhizomes of Asian herbs (including Coptis chinensis Franch), has been used to treat diabetes mellitus for thousands of years. We explored the possibility that CR acts directly on skeletal muscle, the major organ responsible for glucose homeostasis, and activates 5′-AMP-activated protein kinase (AMPK), a signaling intermediary leading to metabolic enhancement of skeletal muscle.

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What this paper is about

Aim Coptidis Rhizoma (CR), the dried rhizomes of Asian herbs (including Coptis chinensis Franch), has been used to treat diabetes mellitus for thousands of years. We explored the possibility that CR acts directly on skeletal muscle, the major organ responsible for glucose homeostasis, and activates 5′-AMP-activated protein kinase (AMPK), a signaling intermediary leading to metabolic enhancement of skeletal muscle.

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OpenAlex reports 4 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Aim Coptidis Rhizoma (CR), the dried rhizomes of Asian herbs (including Coptis chinensis Franch), has been used to treat diabetes mellitus for thousands of years. We explored the possibility that CR acts directly on skeletal muscle, the major organ responsible for glucose homeostasis, and activates 5′-AMP-activated protein kinase (AMPK), a signaling intermediary leading to metabolic enhancement of skeletal muscle.

Key concepts: AMPK, Coptis chinensis, Skeletal muscle, Protein kinase A, AMP-activated protein kinase, Rhizome, Diabetes mellitus, Berberine

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