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A NEW ANTIBODY TEST FOR RUBELLA

Richard H. Michaels, Donald N. Medearis

Open publisher page 1 citations

Abstract

THE development of serologic methods for rubella is of considerable importance; a clinical diagnosis of rubella cannot be made reliably and the hazards of fetal infection with this virus are significant. Recently Stewart, et al. reported the successful application of the hemagglutination-inhibition technique to assay of rubella virus antibodies. With the use of red blood cells from 1-day-old chicks, the authors devised an hemagglutination-inhibition (HI) test which appeared to have the reliability and sensitivity of the standard neutralization test but was simpler, more rapid, and less expensive to perform. Sever and his associates have confirmed and extended these observations in an article which appears elsewhere in this issue.

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What this paper is about

THE development of serologic methods for rubella is of considerable importance; a clinical diagnosis of rubella cannot be made reliably and the hazards of fetal infection with this virus are significant. Recently Stewart, et al. reported the successful application of the hemagglutination-inhibition technique to assay of rubella virus antibodies. With the use of red blood cells from 1-day-old chicks, the authors devised an hemagglutination-inhibition (HI) test which appeared to have the reliability and sensitivity of the standard neutralization test but was simpler, more rapid, and less expensive to perform. Sever and his associates have confirmed and extended these observations in an article which appears elsewhere in this issue.

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Available abstract

THE development of serologic methods for rubella is of considerable importance; a clinical diagnosis of rubella cannot be made reliably and the hazards of fetal infection with this virus are significant. Recently Stewart, et al. reported the successful application of the hemagglutination-inhibition technique to assay of rubella virus antibodies. With the use of red blood cells from 1-day-old chicks, the authors devised an hemagglutination-inhibition (HI) test which appeared to have the reliability and sensitivity of the standard neutralization test but was simpler, more rapid, and less expensive to perform. Sever and his associates have confirmed and extended these observations in an article which appears elsewhere in this issue.

Key concepts: Medicine, Rubella, Rubella virus, Hemagglutination assay, Hemagglutination, Virology, Serology, Hemagglutination tests

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