POEM SYNDROME: A CASE REPORT

“POEMS Syndrome” associated with plasma cell dyscrasia, is an acronym that stands for uncommon syndrome involving multisystem.  The major features are chronic progressive sensorimotor polyneuropathy, organomegaly (mainly hepatomegaly and lymphadenopathy) endocrinopathy (especially gonadal failure and diabetes mellitus), monoclonal gammopathy and skin changes.  In typical case, papilledema, high CSF pressure and CSF potein, anasarca and clubbing of fingers are found. Most cases were reported from Japan, and rarely reported from United States, Europe and other parts of Asia. We report a Thai woman who initially presented with chronic diarrhea, edema and kin changes, then the other complete features of POEMS syndrome were revealed later.