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1988•Chemical and Pharmaceutical BulletinOpen access

Synthesis and aldose reductase-inhibitory activities of structural analogues of WF-3681, a novel aldose reductase inhibitor.

Takayuki Namiki, Yukihisa Baba, Yasutaka Suzuki, MOTOAKI NISHIKAWA, Kozo Sawada, Yoshikuni Itoh, Teruo Oku, Yoshihiko Kitaura, Masashi Hashimoto

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Abstract

Various analogues of WF-3681 (1a), a novel aldose reductase inhibitor, were synthesized and examined for aldose reductase-inhibitory activity. It was found that the carboxylic acid function is necessary and the side-chain length is important for the activity. Furthermore, the lipophilicities of the benzene ring and the enol ether group are significant for increasing the activity.

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Various analogues of WF-3681 (1a), a novel aldose reductase inhibitor, were synthesized and examined for aldose reductase-inhibitory activity. It was found that the carboxylic acid function is necessary and the side-chain length is important for the activity. Furthermore, the lipophilicities of the benzene ring and the enol ether group are significant for increasing the activity.

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Available abstract

Various analogues of WF-3681 (1a), a novel aldose reductase inhibitor, were synthesized and examined for aldose reductase-inhibitory activity. It was found that the carboxylic acid function is necessary and the side-chain length is important for the activity. Furthermore, the lipophilicities of the benzene ring and the enol ether group are significant for increasing the activity.

Key concepts: Aldose reductase, Chemistry, Aldose reductase inhibitor, Aldose, Stereochemistry, Enzyme inhibitor, Sorbinil, Side chain

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Synthesis and aldose reductase-inhibitory activities of structural analogues of WF-3681, a novel aldose reductase inhibitor. — Research Paper | ScholarLens