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Cimetidine in the treatment of refractory anaphylaxis.

Jill Yarbrough, John E. Moffitt, Dorothy A. Brown, Chester T. Stafford

Open publisher page 25 citations

Abstract

After preoperative intubation and administration of intravenous cefuroxime, a 48-year-old white female developed anaphylactic shock that was refractory to the usual therapeutic measures but was responsive to treatment with intravenous cimetidine. Beta-lactam sensitivity was subsequently confirmed by skin testing. Cimetidine, which antagonizes arterial H2 receptors, may be useful in the treatment of anaphylaxis refractory to the usual resuscitative measures.

About this research paper

What this paper is about

After preoperative intubation and administration of intravenous cefuroxime, a 48-year-old white female developed anaphylactic shock that was refractory to the usual therapeutic measures but was responsive to treatment with intravenous cimetidine. Beta-lactam sensitivity was subsequently confirmed by skin testing. Cimetidine, which antagonizes arterial H2 receptors, may be useful in the treatment of anaphylaxis refractory to the usual resuscitative measures.

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OpenAlex reports 25 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

After preoperative intubation and administration of intravenous cefuroxime, a 48-year-old white female developed anaphylactic shock that was refractory to the usual therapeutic measures but was responsive to treatment with intravenous cimetidine. Beta-lactam sensitivity was subsequently confirmed by skin testing. Cimetidine, which antagonizes arterial H2 receptors, may be useful in the treatment of anaphylaxis refractory to the usual resuscitative measures.

Key concepts: Medicine, Cimetidine, Anaphylaxis, Refractory (planetary science), Ranitidine, Anesthesia, Cefuroxime, Shock (circulatory)

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