1997•Phytotherapy ResearchRequires access

Evaluation of diuretic activity ofAlternanthera pungens extract in rats

Claudia Patricia Calderón, Susana B. García Aseff, Lucía B. Fuentes

Abstract

A pharmacological evaluation for diuretic activity of the ethanol extract of Alternanthera pungens was carrried out. Urinary excretion of water, pH, density and sodium concentration were investigated in isotonic saline loaded rats. The extract showed an effective diuretic activity, in comparison with furosemide, increasing significantly the renal loss of sodium. These results indicate that this plant has a diuretic behaviour similar to furosemide, a high-ceiling diuretic agent. © 1997 John Wiley & Sons, Ltd.

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Key concepts: Diuretic, Furosemide, Diuresis, Sodium, Chemistry, Pharmacology, Loop diuretic, Saline