1972•Journal of Biological ChemistryOpen access

Evidence for Increased Cytoplasmic Androgen Binding in the Submandibular Gland of the Mouse with Testicular Feminization

Jean D. Wilson, Joseph L. Goldstein

Abstract

Utilizingdensity gradient centrifugation, polyacrylamide gel electrophoresis, and equilibrium dialysis, the in uitro binding of [l ,Z3H]dihydrotestosterone by cytoplasmic extracts of submandibular glands from normal mice was compared to that of mice carrying the X-linked gene for testicular feminization (Tjm).

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Available abstract

Key concepts: Feminization (sociology), Testicular feminization, Androgen insensitivity syndrome, Endocrinology, Internal medicine, Submandibular gland, Cytoplasm, Androgen