2007•Unpublished venueRequires access

Regulation of the p53 Tumor‐Suppressor Protein by Ubiquitin and Ubiquitin‐Like Molecules

Dimitris P. Xirodimas

Abstract

This chapter contains sections titled: Functional Domains of p53 The Family of Ubiquitin-like Molecules E3 Ligases for p53 Modification of p53 with Ubiquitin Requirements for Mdm2-mediated Ubiquitination of p53 Regulation of p53 Ubiquitination E2 Conjugating Enzymes Interacting Proteins By Other Post-translational Modifications De-ubiquitination of p53 SUMO-1/sentrin/smpt3 NEDD8/Rub1 Therapeutic Intervention through the Ubiquitin Pathway Acknowledgments References

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Available abstract

Key concepts: Ubiquitin, NEDD8, Mdm2, Ubiquitin-conjugating enzyme, Ubiquitin ligase, Deubiquitinating enzyme, Suppressor, Cell biology