1995•Pharmacy and Pharmacology CommunicationsRequires access
Different Localization of Metallothionein in Mouse Pancreas After Induction by Zinc or Streptozotocin
Takeshi Minami, Hideki Matsubara, Yoshiyuki Tohno, Setsuko Tohno, Masa-oki Yamada, Eizi Kadota, Yoshimitsu Okazaki
Open publisher page 3 citations
Abstract
Localization of metallothionein induced by zinc or streptozotocin treatment was demonstrated in the pancreas of mice by immunohistochemical techniques.
Ten hours after the administration of zinc, a small amount of metallothionein appeared in the nuclei of exocrine cells, and one day after the administration, metallothionein was found mainly in the cytoplasm and interstitium. Metallothionein was not observed in the islets of Langerhans. When streptozotocin was administered to mice, a small amount of metallothionein was found in the cytoplasm of the islets of Langerhans.
These results show that zinc affected mostly exocrine cells and streptozotocin affected mainly endocrine cells, and that metallothionein was produced at locations damaged by zinc or streptozotocin.