Comparison of Two Different Antagonists As Inhibitors of Acriflavine Fastness of Trypanosomes

Summary Esters and amides of aromatic acids, a recently found group of antagonists of trypanocidal arsenoso compounds, share with p-rosaniline hydrochloride the property of also antagonizing the anti-trypanosomal effect of the acridine dye stuff acriflavine. By the method of inhibition of drug resistance it was shown that by combination of acriflavine with the triphenyl methane dye stuff in serial passages the development of acriflavine resistance of Trypanosoma equiperdum was prevented. In similar experiments in which acriflavine and methyl-p-hydroxybenzoate were combined, an acriflavine fast modification of T. equiperdum was obtained which was identical with a strain treated with acriflavine alone. Therefore, the mechanism of action of these two antagonists is probably different.