2001•Methods and principles in medicinal chemistryRequires access
Phage Display Technology for Target Discovery in Drug Delivery Research
Ricardo Mutuberria, Jan‐Willem Arends, Arjan W. Griffioen, Hennie R. Hoogenboom
Open publisher page 4 citations
Abstract
Introduction Phage display technology Introduction to the technology Phage display libraries Introduction Peptide display Antibody display Protein scaffolds Engineering proteins with phage libraries cDNA expression libraries Generation of ligands amenable for targeting Selection of ligands to defined targets Phage display for target identification In vitro selections on complex antigens In vivo selections and selections for functional activity Engineering and optimization for targeting Discovery of novel therapeutics using phage display technology Conclusions