1999•Unpublished venueRequires access
Identification and Characterization of Proteins Involved in Integrin Signaling
Csilla A. Fenczik
Open publisher page 0 citations
Abstract
The development and function of multicellular animals requires integrin adhesion receptors. Integrin-dependent cell adhesion is regulated, in part, by ligand binding affinity ("activation") changes controlled by cellular signaling cascades. Regulation of integrin affinity is important in cell migration, extracellular matrix assembly and morphogenesis. Integrin activation is energy-dependent, and is mediated by cell type specific signals operating through integrin cytoplasmic domains.