Simultaneous UV Spectrophotometric Method for Estimation of Losartan Potssium and Amlodipine Besylate in Tablet Dosage Form

Two simple, accurate, precise, reproducible, requiring no prior separation and economical procedures for simultaneous estimation of Losartan Potassium and Amlodipine Besylate in tablet dosage form have been developed. First method employs formation and solving of simultaneous equation using 208 nm and 237.5 nm as two analytical wavelengths for both drugs in methanol. The second method is Q value analysis based on measurement of absorptivity at 242.5 nm (as an iso-absorptive point) and 237.5 nm. Losartan Potassium and Amlodipine Besylate at their respective λmax 208 nm and 237.5 nm and at isoabsorptive point 242.5 nm shows linearity in a concentration range of 2–20 μg/mL. Recovery studies range from 99.95% for Losartan Potassium and 99.33% for Amlodipine Besylate in case of simultaneous equation method and 102.93% for Losartan Potassium and 101.02% for Amlodipine Besylate in case of Q -analysis method confirming the accuracy of the proposed method. The proposed method is recommended for routine analysis since it is rapid, simple, accurate and also sensitive and specific by no heating and no organic solvent extraction.