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Conference on obstacles to the control of acute leukemia. Limitations on the therapeutic effectiveness of the folic acid antagonists.

William C. Werkheiser

Open publisher page 16 citations

Abstract

Suspected causes of the limitations of the therapeutic effectiveness of the folic acid antagonists, amethopterin in particular, are presented. An hypothesis is elaborated, emphasizing the dynamic nature of the processes involved in drug intoxication. A variety of experimental and clinical chemotherapeutic regimens are reviewed in terms of this hypothesis, and modifications of both the tissue permeability and the stereochemistry of the anti-metabolites are discussed.

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What this paper is about

Suspected causes of the limitations of the therapeutic effectiveness of the folic acid antagonists, amethopterin in particular, are presented. An hypothesis is elaborated, emphasizing the dynamic nature of the processes involved in drug intoxication. A variety of experimental and clinical chemotherapeutic regimens are reviewed in terms of this hypothesis, and modifications of both the tissue permeability and the stereochemistry of the anti-metabolites are discussed.

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OpenAlex reports 16 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Suspected causes of the limitations of the therapeutic effectiveness of the folic acid antagonists, amethopterin in particular, are presented. An hypothesis is elaborated, emphasizing the dynamic nature of the processes involved in drug intoxication. A variety of experimental and clinical chemotherapeutic regimens are reviewed in terms of this hypothesis, and modifications of both the tissue permeability and the stereochemistry of the anti-metabolites are discussed.

Key concepts: Amethopterin, Folic Acid Antagonists, Folic acid, Medicine, Pharmacology, Leukemia, Drug, Acute leukemia

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Conference on obstacles to the control of acute leukemia. Limitations on the therapeutic effectiveness of the folic acid antagonists. — Research Paper | ScholarLens