Micropunctate fluorescein staining of the human corneal surface: microerosions or cystic spaces?

PURPOSE: To study in vivo the phenomenon of micropunctate fluorescein staining of the human corneal surface. METHODS: Patients were examined in the slit-lamp and photographed by the means of photomicrography. The staining pattern of fluorescein was compared with that of superimposed rose bengal staining. RESULTS: The staining patterns showed a great correspondence. CONCLUSION: The findings indicate that micropunctate fluorescein staining probably reveals disruptions of intercellular junctions permitting penetration and accumulation of stained fluid beneath diseased cells in situ.