Leveraging Large‐Scale Approaches to Dissect the Rhizobia–Legume Symbiosis

A hallmark trait of legumes is their availability to develop root nodules and to fix nitrogen in symbiosis with compatible rhizobia. The development of this symbiotic process is generally characterized by a high level of host specificity and is coordinately regulated by the mutual exchange of diffusible signal molecules. Although genetic approaches have led to the identification of different genes involved in the control of the legume–rhizobia interaction, it is likely that additional “players” remain unidentified. Different kinds of large-scale analyses have been recently used to dissect the molecular events that occur during the legume–rhizobia interaction. Here, we provide an overview of the information generated by transcriptomics and phosphoproteomics analyses in different stages of this symbiosis.