Fructose-2,6-Bisphosphate
Simon J. Pilkis
Abstract
Simon J. Pilkis
Abstract
Historical Perspective and Discovery of Fructose-2,6-Bisphosphate. Effects of Fructose-2,6-Bisphosphate on 6-Phosphofructo 1-Kinase and Fructose-1,6-Bisphosphatase. The Sites of Interaction of Fructose-2,6-Bisphosphate and Fructose-1,6-Bisphosphate with Their Target Enzymes: 6-Phosphofructo-1-Kinase and Fructose-1,6-Bisphosphatase. Analogs of Fructose-2,6-Bisphosphate as Activators of 6-Phosphofructo-1-Kinase and Pyrophosphate-Dependent Phosphofructokinase and as Inhibitors of Fructose-1,6-Bisphosphatase. Role of Fructose-2,6-Bisphosphate in the Regulation of Hepatic Carbohydrate Metabolism. Liver 6-Phosphofructo-2-Kinase/Fructose-2,-6-Bisphosphatase. Tertiary Structure Modeling of 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase: Structural, Funtional, and Evolutionary Design of Bifunctional Enzyme. Fructose-2,6-Bisphosphate in Extra Hepatic Tissues. The Role of Fructose-2,6-Bisphosphate in Plant Tissues. On The Nature of Fructose-2,6-P2 Metabolizing Enzymes in Plants. Role of Fructose-2,6-P2 in Yeast. Fructose-2,6-Bisphosphate in Primitive Systems. The Importance of Being Bifunctional (with Apologies to Oscar Wilde). Reflections on Future Research on Fructose-2,6-Bisphosphate Metabolism. c. 192 pp., 7x10, 1989, ISBN 0-8493-4795-5.
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Historical Perspective and Discovery of Fructose-2,6-Bisphosphate. Effects of Fructose-2,6-Bisphosphate on 6-Phosphofructo 1-Kinase and Fructose-1,6-Bisphosphatase. The Sites of Interaction of Fructose-2,6-Bisphosphate and Fructose-1,6-Bisphosphate with Their Target Enzymes: 6-Phosphofructo-1-Kinase and Fructose-1,6-Bisphosphatase. Analogs of Fructose-2,6-Bisphosphate as Activators of 6-Phosphofructo-1-Kinase and Pyrophosphate-Dependent Phosphofructokinase and as Inhibitors of Fructose-1,6-Bisphosphatase. Role of Fructose-2,6-Bisphosphate in the Regulation of Hepatic Carbohydrate Metabolism. Liver 6-Phosphofructo-2-Kinase/Fructose-2,-6-Bisphosphatase. Tertiary Structure Modeling of 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase: Structural, Funtional, and Evolutionary Design of Bifunctional Enzyme. Fructose-2,6-Bisphosphate in Extra Hepatic Tissues. The Role of Fructose-2,6-Bisphosphate in Plant Tissues. On The Nature of Fructose-2,6-P2 Metabolizing Enzymes in Plants. Role of Fructose-2,6-P2 in Yeast. Fructose-2,6-Bisphosphate in Primitive Systems. The Importance of Being Bifunctional (with Apologies to Oscar Wilde). Reflections on Future Research on Fructose-2,6-Bisphosphate Metabolism. c. 192 pp., 7x10, 1989, ISBN 0-8493-4795-5.
Key concepts: Fructose 2,6-bisphosphate, Phosphofructokinase 2, Fructose, Fructose 1,6-bisphosphatase, Fructolysis, Biochemistry, Aldolase B, Chemistry