2010•Unpublished venueRequires access

Gastric Acid Secretion and Hormones

Geoffrey Spencer, David C. Metz

Abstract

Gastric acid secretion is crucial to initiate digestion and absorption of ingested nutrients. An intricate neurohormonal system regulates hydrogen secretion from the proton pump (H+, K+-ATPase enzyme) located on the apical membrane of the parietal cell. Gastrin is released from G cells located in the gastric antrum and stimulates enterochromaffin-like (ECL) cells to release histamine which in turn directly activates acid secretion from the nearby parietal cell. Acetylcholine release from vagal stimulation also results in stimulation of the parietal cell and hydrogen secretion. This system is kept in balance by the inhibitory influence of

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Available abstract

Key concepts: Parietal cell, Secretion, Regulation of gastric function, Enterochromaffin-like cell, G cell, Enterochromaffin cell, Gastric acid, Gastrin