ScholarLens Back to search
1967•Journal of Biological ChemistryOpen access

Biosynthesis of α, ε-Diaminopimelic Acid in Bacillus megaterium

Gnanasigamoni Sundharadas, Charles Gilvarg

Open full text 45 citations

Abstract

Abstract A diaminopimelic acid auxotroph of Bacillus megaterium was shown to accumulate N-acetyl-l-diaminopimelic acid. Extracts prepared from cultures of the parental strain contain N-acetyl-l-diaminopimelic acid deacylase but this enzyme was absent in extracts prepared from the mutant. Apparently acetate is used as the blocking group in diaminopimelate biosynthesis in B. megaterium in contrast to succinate which has the analogous function in Escherichia coli.

About this research paper

What this paper is about

Abstract A diaminopimelic acid auxotroph of Bacillus megaterium was shown to accumulate N-acetyl-l-diaminopimelic acid. Extracts prepared from cultures of the parental strain contain N-acetyl-l-diaminopimelic acid deacylase but this enzyme was absent in extracts prepared from the mutant. Apparently acetate is used as the blocking group in diaminopimelate biosynthesis in B. megaterium in contrast to succinate which has the analogous function in Escherichia coli.

Why it matters

OpenAlex reports 45 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Abstract A diaminopimelic acid auxotroph of Bacillus megaterium was shown to accumulate N-acetyl-l-diaminopimelic acid. Extracts prepared from cultures of the parental strain contain N-acetyl-l-diaminopimelic acid deacylase but this enzyme was absent in extracts prepared from the mutant. Apparently acetate is used as the blocking group in diaminopimelate biosynthesis in B. megaterium in contrast to succinate which has the analogous function in Escherichia coli.

Key concepts: Bacillus megaterium, Diaminopimelic acid, Biosynthesis, Microbiology, Chemistry, Biochemistry, Biology, Bacteria

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Biosynthesis of α, ε-Diaminopimelic Acid in Bacillus megaterium — Research Paper | ScholarLens