Diagnostic and therapeutic procedures in the vulvar intraepithelial neoplasia (VIN) and early invasive cancer of the vulva.

The study comprised 71 women from 1st Clinic of Gynecology Medical Academy of Cracow from 30 to 76 years (means = 52.5) with VIN and early invasive cancer of the vulva. The clinical examination, colposcopy, cytology, histology of target biopsy and culture of microorganisms taken from the vulva were performed in all cases. 36 cases with VIN I, 14 cases with VIN II, 17 cases with VIN III and 4 cases with early invasive carcinoma were found. The local anti-inflammatory procedure was used in all cases with VIN I, 8 cases with VIN II and 4 cases with VIN III. In 6 women with VIN III and in 3 with VIN II lyocal excision of unifocal lesions was performed. In 4 women with VIN III and 4 with the early invasive carcinoma simple vulvectomy was applied. After treatment with local anti-inflammatory agents, the total regression of the lesion was observed in 92.9% cases with VIN I, and 75% with VIN II. In 6 women treated with cryocoagulation positive therapeutic effects were noted. In 1 out of 6 cases with VIN III treated by the local excision, the recurrence of the lesion was observed. Among 8 women, after simple vulvectomy, 5 cases have been observed for more than 5 years, and are considered cured.