1984•Applied and Environmental MicrobiologyOpen access

Chloramphenicol acetyltransferase should not provide methanogens with resistance to chloramphenicol

Gregory S. Beckler, Laura Hook, John N. Reeve

Abstract

Growth of the four methanogens investigated was inhibited by chloramphenicol-3-acetate; therefore, introduction of chloramphenicol acetyltransferase-encoding genes should not confer chloramphenicol resistance on these methanogens. Reduction of the aryl nitro group of chloramphenicol produced a compound which did not inhibit the growth of these methanogens.

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Key concepts: Chloramphenicol, Chloramphenicol acetyltransferase, Microbiology, Biology, Acetyltransferase, Gene, Chemistry, Antibiotics