2010•Methods and principles in medicinal chemistryRequires access

Topical and Transdermal Delivery Using Prodrugs: Mechanism of Enhancement

Kenneth B. Sloan, Scott Wasdo, Susruta Majumdar

Abstract

This chapter contains sections titled: Introduction Arrangement of Water in the Stratum Corneum A New Model for Diffusion Through the Stratum Corneum: The Biphasic Solubility Model Equations for Quantifying Effects of Solubility on Diffusion Through the Stratum Corneum Design of Prodrugs for Topical and Transdermal Delivery Based on the Biphasic Solubility Model Comparison of Human and Mouse Skin Experiments Summary References

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Available abstract

Key concepts: Stratum corneum, Transdermal, Solubility, Prodrug, Skin barrier, Lipophilicity, Chemistry, Diffusion