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Nerve Growth Factor and Sepsis

Ayse Belin, Mustafa Kemal Bayar

Abstract

Neurotrophins are a family of growth factors that are polypeptide in structure and are necessary for the development and maintenance of the vertebrate nervous system. The first member of this family, nerve growth factor (NGF) was discovered in 1952 by an Italian group of scientists led by Rita Levi-Montalcini. She received a Nobel Prize in 1987 for her team’s discovery. A few decades after the discovery of NGF, brain-derived neurotrophin factor (BDNF), neurotrophin-3 (NT-3), neurotrophin-4 (NT-4), and neurotrophin-5 (NT-5) were discovered, followed by neurotrophin-6 (NT-6) and neurotrophin-7 (NT-7) [1-3].

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Key concepts: Neurotrophin, Nerve growth factor, Neurotrophin-3, Neuroscience, Neurotrophic factors, Brain-derived neurotrophic factor, Biology, Genetics