2003•Methods and principles in medicinal chemistryRequires access
Prediction of Bioavailability
Arun K. Mandagere, Barry Jones
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Abstract
This chapter contains sections titled: Introduction Oral Bioavailability Definition Cassette Dosing Across-species Prediction of Bioavailability In silico Models for Estimating Human Oral Bioavailability Quantitative Structure–Activity Relationship (QSAR) Approaches Molecular Properties Influencing Bioavailability Estimation of Bioavailability from Calculated Absorption ACE Inhibitors β-Blockers Calcium Antagonists In vitro Model for Predicting Oral Bioavailability in Human and other Species In vivo Method for Estimating Human Oral Bioavailability from Animal Pharmacokinetic Studies Factors to Consider in Optimizing Oral Bioavailability