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1988•The Journal of ImmunologyRequires access

Evidence that leukocyte function-associated antigen-1 is involved in recirculation and homing of human lymphocytes via high endothelial venules.

Steven T. Pals, Annelies den Otter, Frank Miedema, Peter J. Kabel, Gerrit D. Keizer, Rik J. Scheper, C. J. L. M. Meijer

Open publisher page 115 citations

Abstract

We report the results of mAb inhibition studies of human lymphocyte-high endothelial venule interaction in vitro. These studies in which T cells from both normal donors and from a LFA-1-deficient patient were used indicate that in addition to a system of organ-specific 90-kDa "homing" receptors on lymphocytes, LFA-1 is also involved in lymphocyte recirculation and homing.

About this research paper

What this paper is about

We report the results of mAb inhibition studies of human lymphocyte-high endothelial venule interaction in vitro. These studies in which T cells from both normal donors and from a LFA-1-deficient patient were used indicate that in addition to a system of organ-specific 90-kDa "homing" receptors on lymphocytes, LFA-1 is also involved in lymphocyte recirculation and homing.

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OpenAlex reports 115 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

We report the results of mAb inhibition studies of human lymphocyte-high endothelial venule interaction in vitro. These studies in which T cells from both normal donors and from a LFA-1-deficient patient were used indicate that in addition to a system of organ-specific 90-kDa "homing" receptors on lymphocytes, LFA-1 is also involved in lymphocyte recirculation and homing.

Key concepts: Homing (biology), Lymphocyte homing receptor, High endothelial venules, Venule, Immunology, Lymphocyte, Receptor, Biology

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Evidence that leukocyte function-associated antigen-1 is involved in recirculation and homing of human lymphocytes via high endothelial venules. — Research Paper | ScholarLens