2012•Journal of Postgraduate Medical InstituteOpen access
A COMPARATIVE ANALYSIS OF IN-HOSPITAL LEFT VENTRICULAR FUNCTION IN PATIENTS WITH SUCCESSFUL OR UNSUCCESSFUL STREPTOKINASE THROMBOLYSIS FOLLOWING ACUTE MYOCARDIAL INFARCTION
Sher Bahadar Khan, Rafiullah, Hafiz Ur Rehman, Tariq Nawaz, Syed Tahir Shah, Syed Sadiq Shah, Hameedullah, Abdul Hadi, Muhammad Hafizullah, Adnan Mahmood Gul, Hikmatullah Jan, Syed Farhat Abbas Shah
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Abstract
Objective: To compare in-hospital left ventricular function in patients with unsuccessful and successfulthrombolysis presenting with acute myocardial infarction treated with streptokinase. Methodology: This comparative study was conducted at department of Cardiology, Lady Reading HospitalPeshawar, from October 2006 to October 2007. Two hundred patients with first acute myocardial infarctionwere divided into two groups: group A (successful thrombolysis) and group B (unsuccessful thrombolysis),using ECG criteria. To determine Left Ventricular Function, 2-D Echo was used. Results: Group A included 136 (68%) patients and group B included 64 (32%) patients. Impaired leftventricular function was found in 41 (30.1%) patients in group A and 41 (64.1%) patients in group B (p<0.001). Left ventricular failure was present in 31 (22.8%) patients of group A and 30 (46.9%) patients ofgroup B (p=0.001). Cardiogenic shock was diagnosed in 2 (1.5%) patients in group A and 6 (9.4%)patients in group B (p=0.008). Conclusion: Presence of LVF is strongly associated with unsuccessful thrombolytic therapy in this groupof patients.