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2014•Journal of Parkinson s DiseaseOpen access

An Update of the Impact of Deep Brain Stimulation on Non Motor Symptoms in Parkinson's Disease

Lisa Klingelhoefer, Michael Samuel, К. Ray Chaudhuri, Keyoumars Ashkan

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Abstract

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a well-established therapy for patients with Parkinson's disease (PD), especially those with advanced motor complications. The effect of STN DBS on non motor symptoms (NMS) of PD is less well studied. In this article, we review the pertinent literature on the impact of STN DBS on NMS when they co-exist with disabling motor symptoms in PD patients. We also present evidence that the number and the severity of most NMS decrease after STN DBS which can have a major impact on patients' quality of life.

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What this paper is about

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a well-established therapy for patients with Parkinson's disease (PD), especially those with advanced motor complications. The effect of STN DBS on non motor symptoms (NMS) of PD is less well studied. In this article, we review the pertinent literature on the impact of STN DBS on NMS when they co-exist with disabling motor symptoms in PD patients. We also present evidence that the number and the severity of most NMS decrease after STN DBS which can have a major impact on patients' quality of life.

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OpenAlex reports 30 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a well-established therapy for patients with Parkinson's disease (PD), especially those with advanced motor complications. The effect of STN DBS on non motor symptoms (NMS) of PD is less well studied. In this article, we review the pertinent literature on the impact of STN DBS on NMS when they co-exist with disabling motor symptoms in PD patients. We also present evidence that the number and the severity of most NMS decrease after STN DBS which can have a major impact on patients' quality of life.

Key concepts: Deep brain stimulation, Subthalamic nucleus, Parkinson's disease, Motor symptoms, Medicine, Physical medicine and rehabilitation, Quality of life (healthcare), Disease

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