2003•Iranian journal of medical sciencesOpen access

Role of IgE Low-Affinity Receptor (CD23) in Pathogenesis of Nasal Polyp

Fardin Eghtedari, Mehdi Askari, Abbas Ali Ghaderi, S Kashef

Abstract

Background: Nasal polyps, a common clinical problem, are characterized by eosinophilic and mast cell inflammation. The role of allergy and IgE in pathogenesis of nasal polyps is still unclear. IgE receptors are important components of the immunological pathway in allergic and inflammatory diseases. Objective: To determine if the low affinity IgE receptor (CD23) is presented on nasal polyp tissues as a marker of local allergy or inflammation.

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Key concepts: Immunoglobulin E, Medicine, CD23, Pathogenesis, Nasal polyps, Immunology, Allergy, Inflammation