2007•Unpublished venueRequires access

Stimulation of Toll‐Like Receptor 9 for Enhancing Vaccination

Daniel E. Speiser, Arthur Μ. Krieg

Abstract

This chapter contains sections titled: Introduction The Role of TLR9 as Receptor for CpG ODN Identification of Distinct Classes of Immune Stimulatory CpG ODN CpG ODN Mechanisms Action in Stimulating Innate and Adaptive Immunity CpG ODN as Adjuvants for Infectious Disease Vaccines CpG ODN Synergy with other Adjuvants Human Clinical Trials with CpG ODN to Adjuvant Infectious Disease Vaccines Efficacy of CpG ODN as Vaccine Adjuvants in Mouse Tumor Models Human Clinical Trials of CpG ODN Adjuvants for Cancer Vaccines Safety of CpG ODN as Vaccine Adjuvant Conclusions References

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Key concepts: CpG Oligodeoxynucleotide, TLR9, Adjuvant, CpG site, Immunology, Toll-Like Receptor 9, Immune system, Vaccination